Have you heard of Histamine Intolerance and/or Mast Cell Activation Syndrome/Disorder (MCAS)? These are two very related conditions that can account for a lot of intestinal and systemic symptomatology.

Histamine is a substance released from mast cells, basophils, platelets and certain neurons (mostly in the hypothalamus in our brains), and enterochromaffin cells in skin and intestine. It is released when a cell is triggered by something it reacts to. For example, being allergic to orange tree blossoming causes you to sneeze and have a runny nose--that is your cells releasing histamine when the pollen activated it.